So I now have two different installs on WIndows 10 x64 with the latest annual update (1607) and neither will go into edit mode or creating a new file or managing licensing or users.
Even though NI Licence Manager reports full development license is activated/good, Lookout Registration info reports:
Serial No: A00S00000
Not registered.
License type: Runtime/Client license
Unlimited I/O points.
This needs to be fixed!